Complement C3d Antibody (053A-1149.3.1.4 (1003))

Validated:

Cited:

Validated:

Cited:

Unconjugated

Monoclonal Mouse IgG₁ Clone # 053A-1149.3.1.4 (1003)

Please see the vial label for concentration. If unlisted please contact technical services.

Purified C3d from human plasma

NB100-65510 is specific for human complement component 3d (C3d), a 33kDa polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Monoclonal

Mouse

IgG₁

Protein A purified

Borate buffered saline (pH 8.4)

0.1% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.