Complement C3d Antibody (3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51119

Novus Biologicals, part of Bio-Techne
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NBP1-51119
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Functional, Immunoassay, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 3

Concentration

0.1 mg/ml

View all Complement C3d Antibodies »

Product Specifications

Immunogen

The monocolonal antibody 3 (also known as YB2/39-11-1-7) reacts with a linear determinant in C3d.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for Complement C3d Antibody (3)

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.2 um filtered solution in PBS and 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement C3d

The monocolonal antibody 3 (also known as YB2/39-11-1-7) reacts with a linear determinant in C3d. This 'D' antigen is found on C3, C3b, iC3b, C3dg and C3d. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g, though this does not occur in plasma. The monoclonal antibody 3 recognizes C3, C3b, iC3b, C3dg and C3d. The monoclonal antibody does not recognize C3c. To distinguish C3 from C3b an anti-C3a antibody is necessary (HM2074).

Alternate Names

AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, complement C3, complement component 3, complement component C3, CPAMD1acylation-stimulating protein cleavage product

Entrez Gene IDs

718 (Human)

Gene Symbol

C3

UniProt

P01024

Additional Complement C3d Products

Product Documents for Complement C3d Antibody (3)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Complement C3d Antibody (3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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