Complement Factor H Antibody (028B-244.2.10X (10-10))

Unconjugated

Monoclonal Mouse IgG₁ Clone # 028B-244.2.10X (10-10)

1.0 mg/ml

Purified human complement factor H from serum

NB100-64342 recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.

Monoclonal

Mouse

IgG₁

Protein A purified

Borate buffered saline (pH 8.4)

0.1% Sodium Azide

1.0 mg/ml

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.