Complement Factor MASP3/MASP1 Antibody (4H2A9)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11225

Novus Biologicals, part of Bio-Techne
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NBP3-11225
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Key Product Details

Species Reactivity

Human

Applications

Immunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4H2A9

Concentration

0.1 mg/ml

View all Complement Factor MASP3 Antibodies »

Product Specifications

Immunogen

CCP-1 domain of MASP-1

Specificity

The monoclonal antibody 4H2A9 reacts with the CCP1 domain, which is shared by MASP-1, MASP-3 and MAp-44.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Complement Factor MASP3/MASP1 Antibody (4H2A9)

Application
Recommended Usage

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
The monoclonal antibody 4H2A9 is suitable for western blotting and immunoprecipitation experiments. Moreover, the antibody can be used in immunoassays detecting MASP-1, MASP-3 and/or MAp44. For Immunoassay dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement Factor MASP3

The monoclonal antibody 4H2A9 reacts with the CCP1 domain, which is shared by MASP-1, MASP-3 and MAp-44. In total 5 MASP proteins have been identified (MASP-1, MASP-2, MASP-3, MAp19 and MAp44) which are encoded by 2 genes. The MASP-2 gene gives rise to MASP2 and MAp19 due to alternative splicing, whereas the MASP-1 gene encodes a primary transcript which can be spliced to three different mRNAs coding for MASP-1, MASP-3 and MAp44 having molecular weights of 88, 89 and 44kDa, respectively. On the protein level MASP-1 and MASP-2 are shown to be responsible for complement activation through proteolytic cleavage of C2 and C4, whereas MASP-3 has been suggested to inhibit the generation of the C3 convertase. So far the role of the truncated proteases MAp44 and Map19 remain unknown. The monoclonal antibody 4H2A9 is suitable for western blotting and immunoprecipitation experiments. Moreover, the antibody can be used in immunoassays detecting MASP-1, MASP-3 and/or MAp44.

Long Name

Mannan-binding lectin-Associated Serine Protease 3

Alternate Names

MASP1

Gene Symbol

MASP1

Additional Complement Factor MASP3 Products

Product Documents for Complement Factor MASP3/MASP1 Antibody (4H2A9)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Complement Factor MASP3/MASP1 Antibody (4H2A9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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