COMT Antibody (9Y2A3)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16413

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16413-100ul
NBP3-16413-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 9Y2A3

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all COMT Antibodies »

Product Summary for COMT Antibody (9Y2A3)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human COMT (P21964). MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIV

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COMT Antibody (9Y2A3)

Western Blot: COMT Antibody (9Y2A3) [NBP3-16413]

Western Blot: COMT Antibody (9Y2A3) [NBP3-16413]

Western Blot: COMT Antibody (9Y2A3) [NBP3-16413] - Western blot analysis of extracts of various cell lines, using COMT Rabbit mAb (NBP3-16413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Western Blot: COMT Antibody (9Y2A3) [NBP3-16413]

Western Blot: COMT Antibody (9Y2A3) [NBP3-16413]

Western Blot: COMT Antibody (9Y2A3) [NBP3-16413] - Western blot analysis of extracts of various cell lines, using COMT Rabbit mAb (NBP3-16413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Applications for COMT Antibody (9Y2A3)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: COMT

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.

Long Name

Catechol O-Methyltransferase

Alternate Names

catechol O-methyltransferase, catechol-O-methyltransferase, EC 2.1.1.6

Gene Symbol

COMT

Additional COMT Products

Product Documents for COMT Antibody (9Y2A3)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for COMT Antibody (9Y2A3)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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