COP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00114769-D01P

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
H00114769-D01P
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all COP Antibodies »

Product Specifications

Immunogen

COP1 (NP_443121.1, 1 a.a. - 97 a.a.) full-length human protein. MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAETLGLSAGPIPGN

Specificity

Reacts with caspase-1 dominant-negative inhibitor pseudo-ICE.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COP Antibody

Western Blot: COP Antibody [H00114769-D01P]

Western Blot: COP Antibody [H00114769-D01P]

Western Blot: COP Antibody [H00114769-D01P] - Analysis of CARD16 expression in human spleen.
Western Blot: COP Antibody [H00114769-D01P]

Western Blot: COP Antibody [H00114769-D01P]

Western Blot: COP Antibody [H00114769-D01P] - Analysis of CARD16 expression in transfected 293T cell line by CARD16 polyclonal antibody.Lane 1: COP1 transfected lysate(10.70 KDa).Lane 2: Non-transfected lysate.

Applications for COP Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: COP

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of theproteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release ofIL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokineresponse. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, andstaurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspasesCASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Alternate Names

CARD only domain-containing protein 1, CARD only protein, caspase recruitment domain family, member 16, Caspase-1 inhibitor COP, COP1caspase-1 dominant-negative inhibitor pseudo-ICE, COPcaspase recruitment domain-containing protein 16, EC 3.4.22.36, Pseudo interleukin-1 beta converting enzyme, pseudo interleukin-1beta converting enzyme, Pseudo-ICE

Entrez Gene IDs

114769 (Human)

Gene Symbol

CARD16

UniProt

NP_443121.1 (Human)

Additional COP Products

Product Documents for COP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for COP Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.