COP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-30778

Novus Biologicals, part of Bio-Techne
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NBP2-30778
NBP2-30778-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all COP Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: LHKGSLYPRIPGLGKELQTGTHKLS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COP Antibody

Immunohistochemistry-Paraffin: COP Antibody [NBP2-30778]

Immunohistochemistry-Paraffin: COP Antibody [NBP2-30778]

Immunohistochemistry-Paraffin: COP Antibody [NBP2-30778] - Staining of human nasopharynx shows strong cytoplasmic positivity in respiratory epithelial cells.

Applications for COP Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: COP

Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of theproteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release ofIL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokineresponse. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, andstaurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspasesCASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2

Alternate Names

CARD only domain-containing protein 1, CARD only protein, caspase recruitment domain family, member 16, Caspase-1 inhibitor COP, COP1caspase-1 dominant-negative inhibitor pseudo-ICE, COPcaspase recruitment domain-containing protein 16, EC 3.4.22.36, Pseudo interleukin-1 beta converting enzyme, pseudo interleukin-1beta converting enzyme, Pseudo-ICE

Gene Symbol

CARD16

UniProt

Q5EG05 (Human)

Additional COP Products

Product Documents for COP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for COP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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