Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (100%), Xenopus (100%), Zebrafish (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all COP9 signalosome complex subunit 2 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human COP9 constitutive photomorphogenic homolog subunit 2 using the numbering given in entry NP_004227.1 (GeneID 9318).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COP9 signalosome complex subunit 2 Antibody

Western Blot: COP9 signalosome complex subunit 2 Antibody [NB100-363]

Western Blot: COP9 signalosome complex subunit 2 Antibody [NB100-363]

Western Blot: COP9 signalosome complex subunit 2 Antibody [NB100-363] - Detection of Human CSN2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-CSN2 antibody NB100-363 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Immunohistochemistry-Paraffin: COP9 signalosome complex subunit 2 Antibody [NB100-363]

Immunohistochemistry-Paraffin: COP9 signalosome complex subunit 2 Antibody [NB100-363]

Immunohistochemistry-Paraffin: COP9 signalosome complex subunit 2 Antibody [NB100-363] - Section of human prostate carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-CSN2 used at a dilution of 1:5,000 (0.2ug/ml) and 1:1,000 (1ug/ml). Detection: DAB

Applications for COP9 signalosome complex subunit 2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:1000 - 1:5000

Western Blot

1:1000-1:10000
Application Notes
By Western blot, this antibody recognizes a band at ~50 kDa, representing CSN2 protein. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: COP9 signalosome complex subunit 2

COP9 signalosome is a conserved protein composed of eight subunits. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control. CSN2 is a transcriptional corepressor that encodes the second subunit of COP9 signalosome. CSN2 interacts with and regulates a subset of nuclear hormone receptors and is considered a novel repressor. It also plays a critical role in neuronal differentiation.

Alternate Names

ALIEN, Alien homolog, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), COP9 signalosome complex subunit 2, CSN2JAB1-containing signalosome subunit 2, SGN2TR-interacting protein 15, Signalosome subunit 2, thyroid receptor interacting protein 15, Thyroid receptor-interacting protein 15, TRIP15TRIP-15

Entrez Gene IDs

9318 (Human)

Gene Symbol

COPS2

UniProt

NP_004227.1 (Human)

Additional COP9 signalosome complex subunit 2 Products

Product Documents for COP9 signalosome complex subunit 2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for COP9 signalosome complex subunit 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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