COPB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-2915

Novus Biologicals, part of Bio-Techne
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NB120-2915
NB120-2915-0.025mg
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Key Product Details

Species Reactivity

Human, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all COPB2 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues K(494) V L A A Q E T H E G V T E D G I E(511) of rat beta-COP.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 23845592).

Specificity

Detects coatomer-protein I beta (COP I beta).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COPB2 Antibody

Western Blot: COPB2 Antibody [NB120-2915]

Western Blot: COPB2 Antibody [NB120-2915]

Western Blot: COPB2 Antibody [NB120-2915] - Analysis of Beta-COP from PC-12 cell lysates.

Applications for COPB2 Antibody

Application
Recommended Usage

Flow Cytometry

3-5 ug/10^6 cells

Immunocytochemistry/ Immunofluorescence

2 ug/ml

Western Blot

2 ug/ml
Application Notes
ICC/IF usage was reported in scientific literature (PMID: 11056392). WB: Detects an approx. 115 kDa protein representing COP I beta from PC-12 cell extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: COPB2

Coatomer proteins are involved in regulating transport between the endoplasmic reticulum (ER) and the Golgi complex and in intra-Golgi transport. There exist two coatomer-protein mechanisms (COP I and COP I) and although they have mechanistic parallels, they are molecularly distinct. The COP I coat is comprised of seven subunits (alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP) in a complex called coatomer. Assembly of the coatomer (COP I) onto non-clathrin coated vesicles is regulated by ADP-ribosylation factor (ARF). Vesicle formation, budding, fusion, and disassembly is dependent on GDP-GTP exchange, COP I, and ARF. COP I has been shown to facilitate retrograde intracellular transport from the ER to the Golgi complex. By contrast, COP II facilitates anterograde transport between these subcellular organelles. COP II has been shown to be independently and selectively recruited to the ER relative to COP I subunits.

Alternate Names

beta prime subunit, Beta'-coat protein, Beta'-COP, betaprime-COP, coatomer protein complex, subunit beta 2 (beta prime), coatomer subunit beta', p102

Entrez Gene IDs

60384 (Rat)

Gene Symbol

COPB2

Additional COPB2 Products

Product Documents for COPB2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for COPB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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