Corticotropin Releasing Factor Antibody - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB110-81721

Novus Biologicals, part of Bio-Techne
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NB110-81721
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Guinea Pig (Negative)

Cited:

Mouse, Rat

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

ELISA, IF/IHC, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Format

Azide and BSA Free

Concentration

LYOPH mg/ml

View all Corticotropin Releasing Factor Antibodies »

Product Specifications

Immunogen

An 18 amino acid synthetic CRF peptide (H-CEQLAQQAHSNRKLMEII-OH), conjugated to Keyhole Limpet Hemocyanin (KLH).

Reactivity Notes

This antibody recognises CRF in Human, Rat and Mouse. There is no Cross-reactivity with Guinea Pig.

Specificity

Specific for Corticotropin Releasing Factor. Confirmed by Immunohistochemical analysis of Paraffin Embedded Rat Brain (Hypothalamus).

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Scientific Data Images for Corticotropin Releasing Factor Antibody - Azide and BSA Free

Immunohistochemistry: Corticotropin Releasing Factor Antibody - Azide and BSA Free [NB110-81721]

Immunohistochemistry: Corticotropin Releasing Factor Antibody - Azide and BSA Free [NB110-81721]

Immunohistochemistry: Corticotropin Releasing Factor Antibody [NB110-81721] - Immunohistochemical detection of Corticotropin Releasing Factor in Rat Hypothalamic Brain Tissue using a 1ug/ml dilution of Affinity Purified Sheep Anti-CRF . Left is tested using antibody. Right is testing using negative control antibody.

Applications for Corticotropin Releasing Factor Antibody - Azide and BSA Free

Application
Recommended Usage

ELISA

1:100-1:10

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Reconstitution

Reconstitute with 0.02 ml sterilized water.

Formulation

0.05X PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

Background: Corticotropin Releasing Factor

Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH issecreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH hasbeen observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency hasmultiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to productionin the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed inthe placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturitionand delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, inaddition to its metabolic functions, CRH may act as a trigger for parturition. (provided by RefSeq)

Alternate Names

corticoliberin, corticotropin releasing hormone, Corticotropin-releasing hormone, CRFCorticotropin-releasing factor

Entrez Gene IDs

1392 (Human); 12918 (Mouse); 81648 (Rat)

Gene Symbol

CRH

Additional Corticotropin Releasing Factor Products

Product Documents for Corticotropin Releasing Factor Antibody - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Corticotropin Releasing Factor Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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