CSN7b Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00064708-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CSN7b Antibodies »

Product Specifications

Immunogen

COPS7B (NP_073567.1, 1 a.a. - 264 a.a.) full-length human protein. MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH

Specificity

COPS7B - COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis),

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for CSN7b Antibody

Western Blot: CSN7b Antibody [H00064708-B01P]

Western Blot: CSN7b Antibody [H00064708-B01P]

Western Blot: CSN7b Antibody [H00064708-B01P] - Analysis of COPS7B expression in HeLa.
Immunocytochemistry/ Immunofluorescence: CSN7b Antibody [H00064708-B01P]

Immunocytochemistry/ Immunofluorescence: CSN7b Antibody [H00064708-B01P]

Immunocytochemistry/Immunofluorescence: CSN7b Antibody [H00064708-B01P] - Analysis of purified antibody to COPS7B on HeLa cell. (antibody concentration 10 ug/ml)
Western Blot: CSN7b Antibody [H00064708-B01P]

Western Blot: CSN7b Antibody [H00064708-B01P]

Western Blot: CSN7b Antibody [H00064708-B01P] - Analysis of COPS7B expression in transfected 293T cell line by COPS7B polyclonal antibody. Lane 1: COPS7B transfected lysate(29.04 KDa). Lane 2: Non-transfected lysate.

Applications for CSN7b Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against recombinant protein with GST tag on ELISA and western blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: CSN7b

Component of the COP9 signalosome complex (CSN), is a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Alternate Names

Arabidopsis, homolog) subunit 7B, COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis), COP9 signalosome complex subunit 7b, CSN7BMGC111077, FLJ12612, Signalosome subunit 7b

Entrez Gene IDs

64708 (Human)

Gene Symbol

COPS7B

UniProt

NP_073567.1 (Human)

Additional CSN7b Products

Product Documents for CSN7b Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CSN7b Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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