CTDSP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06029

Novus Biologicals, part of Bio-Techne
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NBP1-06029
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Canine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all CTDSP1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-RGKGDQKSAASQK corresponding to internal region according to NP_872580.1.

Epitope

C-RGKGDQKSAASQK

Specificity

This antibody is expected to recognise both reported isoforms (NP_067021.1and NP_872580.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CTDSP1 Antibody

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029]

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029]

Immunohistochemistry-Paraffin: CTDSP1 Antibody [NBP1-06029] - Staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for CTDSP1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: Preliminary experiments gave an approx. 60 kDa band in human spleen, lung and placenta lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 29.2 kDa band according to NP_067021.1 and 29.1 kDa band according to NP_872580.1. The 60 kDa band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CTDSP1

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in theC-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase IItranscription, possibly by controlling the transition from initiation/capping to processive transcript elongation.Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronalcells

Alternate Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) smallphosphatase 1, NIF3, NLI-IF, NLIIFEC 3.1.3.16, NLI-interacting factor 3, SCP1Nuclear LIM interactor-interacting factor 3, Small CTD phosphatase 1, Small C-terminal domain phosphatase 1

Entrez Gene IDs

58190 (Human); 227292 (Mouse); 363249 (Rat)

Gene Symbol

CTDSP1

UniProt

NP_067021.1 (Human)

Additional CTDSP1 Products

Product Documents for CTDSP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CTDSP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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