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CXCR6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-52034

Novus Biologicals, part of Bio-Techne
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NBP1-52034

Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence C-SEDNSKTFSASHN corresponding to C-Terminus according to NP_006555.1.

Epitope

C-SEDNSKTFSASHN

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CXCR6 Antibody

Western Blot: CXCR6 Antibody [NBP1-52034]

Western Blot: CXCR6 Antibody [NBP1-52034]

Western Blot: CXCR6 Antibody [NBP1-52034] - Analysis of CXCR6 in HEK293 lysate (35ug protein in RIPA buffer) using NBP1-52034 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for CXCR6 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:2000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 40-45 kDa band observed in HEK293 lysates (calculated MW of 39.3 kDa band according to NP_006555.1).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CXCR6

Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T-cell antigen T4 (CD4) and a G protein coupled receptor (GPCR). HIV-1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C-X-C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCR's named chemokine (C-X-C) receptor 6 (Bonzo) and G protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes. Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require co-receptors, in addition to CD4, to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV co-receptors. An orphan G protein coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV co-receptor (1-4). Bonzo/STRL33 is used by SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes.

Alternate Names

Bonzo, CD186, CXCR6, STRL33

Entrez Gene IDs

10663 (Human); 80901 (Mouse); 100124593 (Rat)

Gene Symbol

CXCR6

Additional CXCR6 Products

Product Documents for CXCR6 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CXCR6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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