CYBB/NOX2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51928

Novus Biologicals, part of Bio-Techne
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NBP1-51928
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all CYBB/NOX2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-SYLNFARKRIKNP corresponding to internal region according to NP_000388.2.

Epitope

C-SYLNFARKRIKNP

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CYBB/NOX2 Antibody

Immunohistochemistry-Paraffin: CYBB/NOX2 Antibody [NBP1-51928]

Immunohistochemistry-Paraffin: CYBB/NOX2 Antibody [NBP1-51928]

Immunohistochemistry-Paraffin: CYBB/NOX2 Antibody [NBP1-51928] - NBP1-51928 (3.8ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for CYBB/NOX2 Antibody

Application
Recommended Usage

Immunohistochemistry

1-2 ug/ml

Immunohistochemistry-Paraffin

1-2 ug/ml

Peptide ELISA

Detection limit 1:64000
Application Notes
WB: Approx. 85Da band observed in human peripheral blood mononucleocytes lysates is reported in scientific literature (PMID: 3600769). IHC-P: Human spleen shows staining of select cells.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CYBB/NOX2

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.

Long Name

Cytochrome b-245 heavy chain

Alternate Names

CGD91-phox, CYBB, EC 1.-.-.-, gp91-1, gp91-phox, NADPH oxidase 2, NOX2

Entrez Gene IDs

1536 (Human)

Gene Symbol

CYBB

UniProt

NP_000388.2 (Human)

Additional CYBB/NOX2 Products

Product Documents for CYBB/NOX2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CYBB/NOX2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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