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CYP46A1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-16066

Novus Biologicals, part of Bio-Techne
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NBP2-16066

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Predicted:

Rat (90%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human CYP46A1. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Bovine (89%).

Localization

Endoplasmic reticulum membrane; Microsome membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CYP46A1 Antibody

CYP46A1 Antibody

Western Blot: CYP46A1 Antibody [NBP2-16066] -

Western Blot: CYP46A1 Antibody [NBP2-16066] - Whole cell extract (30 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with CYP46A1 antibody [N1C1] (NBP2-16066) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
CYP46A1 Antibody

Immunohistochemistry-Paraffin: CYP46A1 Antibody [NBP2-16066] -

Immunohistochemistry-Paraffin: CYP46A1 Antibody [NBP2-16066] - CYP46A1 antibody [N1C1] detects CYP46A1 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse hippocampus.
CYP46A1 stained by CYP46A1 antibody [N1C1] (NBP2-16066) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
CYP46A1 Antibody

Immunohistochemistry-Paraffin: CYP46A1 Antibody [NBP2-16066] -

Immunohistochemistry-Paraffin: CYP46A1 Antibody [NBP2-16066] - CYP46A1 antibody [N1C1] detects CYP46A1 protein at cytoplasm by immunohistochemical analysis.
Sample: Paraffin-embedded mouse hippocampus.
CYP46A1 stained by CYP46A1 antibody [N1C1] (NBP2-16066) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Applications for CYP46A1 Antibody

Application
Recommended Usage

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: CYP46A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq]

Alternate Names

CH24H, cholesterol 24-hydroxylase, CYP46CP46, Cytochrome P450 46A1, cytochrome P450, family 46, subfamily A, polypeptide 1, cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase), EC 1.14.13.98

Gene Symbol

CYP46A1

UniProt

Additional CYP46A1 Products

Product Documents for CYP46A1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CYP46A1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.