Cytokeratin 4 Antibody (RM355)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18825

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-18825
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM355

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cytokeratin 4 Antibodies »

Product Specifications

Immunogen

A peptide corresponding to the C-terminus of human Cytokeratin 4 (Uniprot # P19013)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cytokeratin 4 Antibody (RM355)

Cytokeratin 4 Antibody (RM355)

Immunohistochemistry: Cytokeratin 4 Antibody (RM355)[NBP3-18825]

Immunohistochemistry: Cytokeratin 4 Antibody (RM355)[NBP3-18825]Immunohistochemical staining of formalin fixed and paraffin embedded human tonsil tissue section using anti-CK-4 rabbit monoclonal antibody (Clone RM355) at a 1:1000 dilution.

Applications for Cytokeratin 4 Antibody (RM355)

Application
Recommended Usage

Immunohistochemistry

1:500-1:1000

Western Blot

1:100-1:1000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C.

Background: Cytokeratin 4

Keratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. White sponge nevus (WSN) is a benign autosomal dominant disorder which affects non-cornifying stratified squamous epithelial. Keratins are expressed in pairs by epithelial cells in a tissue and cell specific manner. The major differentiation specific keratins of the buccal mucosa, nasal, esophageal and anogenital epithelia are CK-4 and CK-13. The tissue distribution and nature of the lesions in patients affected by WSN suggested that mutations in CK-4 and/or CK-13 might be responsible for this disorder (1). K4 and K13 form heterodimers in normal epithelial cells. In humans, K4 is present in all layers of the epidermis at 10 weeks and gradually disappears, starting from the basal layers at 15 weeks and becoming totally absent at around 20 weeks. This period corresponds to the early fetal period when melanoblasts derived from the neural crest migrate through the dermis into the basal layer of the epidermis (2)

Alternate Names

CK4, CK-4, CYK4cytokeratin-4, Cytokeratin-4, FLJ31692, K4cytokeratin 4, keratin 4, keratin, type II cytoskeletal 4, Keratin-4, Type-II keratin Kb4

Gene Symbol

KRT4

Additional Cytokeratin 4 Products

Product Documents for Cytokeratin 4 Antibody (RM355)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cytokeratin 4 Antibody (RM355)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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