DDR1 Antibody (51D6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09168

Novus Biologicals, part of Bio-Techne
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NBP3-09168
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Clone # 51D6

Concentration

1 mg/ml

View all DDR1 Antibodies »

Product Specifications

Immunogen

DDR1-transfected NIH-3T3 cells

Specificity

The mouse monoclonal antibody 51D6 recognizes an extracellular epitope of CD167a, an approximately 97-101 kDa receptor tyrosine kinase expressed mainly on epithelial cells, but also on B cells and dendritic cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgM

Scientific Data Images for DDR1 Antibody (51D6)

Flow Cytometry: DDR1 Antibody (51D6) [NBP3-09168]

Flow Cytometry: DDR1 Antibody (51D6) [NBP3-09168]

Flow Cytometry: DDR1 Antibody (51D6) [NBP3-09168] - Analysis (surface staining) of MCF-7 cell line stained with anti-human CD167a (51D6) purified, GAM-APC (red) in comparison with FMO (fluorescence minus one) sample (black-dashed).

Applications for DDR1 Antibody (51D6)

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Chromatography

Formulation

TBS

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: DDR1

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]

Long Name

Discoidin Domain Receptor 1

Alternate Names

CAK, CD167a, RTK6, TrkE

Gene Symbol

DDR1

Additional DDR1 Products

Product Documents for DDR1 Antibody (51D6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DDR1 Antibody (51D6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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