DISC1 Antibody (4U5N1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16462

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16462-100ul
NBP3-16462-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 4U5N1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DISC1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DISC1 (Q9NRI5). MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPAVGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVS

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DISC1 Antibody (4U5N1)

Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462]

Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462]

Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462] - Western blot analysis of extracts of various cell lines, using DISC1 Rabbit mAb (NBP3-16462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Immunocytochemistry/ Immunofluorescence: DISC1 Antibody (4U5N1) [NBP3-16462]

Immunocytochemistry/ Immunofluorescence: DISC1 Antibody (4U5N1) [NBP3-16462]

Immunocytochemistry/Immunofluorescence: DISC1 Antibody (4U5N1) [NBP3-16462] - Immunofluorescence analysis of U-2 OS cells using DISC1 Rabbit mAb (NBP3-16462) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462]

Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462]

Western Blot: DISC1 Antibody (4U5N1) [NBP3-16462] - Western blot analysis of extracts of various cell lines, using DISC1 Rabbit mAb (NBP3-16462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
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Applications for DISC1 Antibody (4U5N1)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Western Blot

1:500 - 1:1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DISC1

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Long Name

Disrupted in Schizophrenia 1

Alternate Names

C1orf136, SCZD9

Gene Symbol

DISC1

Additional DISC1 Products

Product Documents for DISC1 Antibody (4U5N1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DISC1 Antibody (4U5N1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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