DISC1 Antibody (SR1013)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22665

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22665-100ul
NBP3-22665-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1013

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DISC1 Antibodies »

Product Summary for DISC1 Antibody (SR1013)

Immunogen

A synthesized peptide derived from human DISC1 (Uniprot #: Q9NRI5)

Specificity

Detects endogenous levels of total DISC1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DISC1 Antibody (SR1013)

Western Blot: DISC1 Antibody (SR1013) [NBP3-22665] -

Western Blot: DISC1 Antibody (SR1013) [NBP3-22665] - Western blot analysis using NBP3-22665 in (1) HeLa cell lysate; (2) RAW264.7 cell lysate; (3) PC-12 cell lysate.

Applications for DISC1 Antibody (SR1013)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DISC1

The Disrupted In Schizophrenia gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations. DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins. DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 an beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5. Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.

Long Name

Disrupted in Schizophrenia 1

Alternate Names

C1orf136, SCZD9

Gene Symbol

DISC1

Additional DISC1 Products

Product Documents for DISC1 Antibody (SR1013)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DISC1 Antibody (SR1013)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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