DKC1 Antibody (S02-2D8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14925

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-14925-100ul
NBP3-14925-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-2D8

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DKC1 Antibodies »

Product Summary for DKC1 Antibody (S02-2D8)

Immunogen

A synthetic peptide of human DKC1 (Uniprot#: O60832)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DKC1 Antibody (S02-2D8)

Western Blot: DKC1 Antibody (S02-2D8) [NBP3-14925]

Western Blot: DKC1 Antibody (S02-2D8) [NBP3-14925]

Western Blot: DKC1 Antibody (S02-2D8) [NBP3-14925] - Western blot detection of DKC1 in K562, C6, 3T3, Hela cell lysates using DKC1 Rabbit mAb (1:1000 diluted). Predicted band size: 58kDa. Observed band size: 58kDa.
Immunohistochemistry-Paraffin: DKC1 Antibody (S02-2D8) [NBP3-14925]

Immunohistochemistry-Paraffin: DKC1 Antibody (S02-2D8) [NBP3-14925]

Immunohistochemistry-Paraffin: DKC1 Antibody (S02-2D8) [NBP3-14925] - Immunohistochemistry of DKC1 in paraffin-embedded Human breast cancer tissue using DKC1 Rabbit mAb at dilution 1/50

Applications for DKC1 Antibody (S02-2D8)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000-1/5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DKC1

DKC1 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Alternate Names

CBF5, CBF5 homolog, cbf5p homolog, DKC, dyskeratosis congenita 1, dyskerin, Dyskerin, EC 5.4.99, EC 5.4.99.-, FLJ97620, H/ACA ribonucleoprotein complex subunit 4, NAP57, NOLA4dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein family A member 4, Nucleolar protein NAP57, snoRNP protein DKC1, XAP101

Gene Symbol

DKC1

Additional DKC1 Products

Product Documents for DKC1 Antibody (S02-2D8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DKC1 Antibody (S02-2D8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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