DMTF1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26208

Novus Biologicals, part of Bio-Techne
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NBP2-26208
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all DMTF1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DAHVSKFSDQNSTE corresponding to internal region according to NP_066968.3, NP_001135798.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_066968.3; NP_001135798.1). Reported variants represent identical protein: NP_066968.3, NP_001135799.1

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for DMTF1 Antibody

Western Blot: DMTF1 Antibody [NBP2-26208]

Western Blot: DMTF1 Antibody [NBP2-26208]

Western Blot: DMTF1 Antibody [NBP2-26208] - Staining of Human (A), Mouse (B) and Rat (C) Testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for DMTF1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 70-75 kDa band observed in human, mouse and rat testis lysates (calculated MW of 74.9 kDa band according to NP_001135799.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DMTF1

DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Alternate Names

cyclin D binding myb-like transcription factor 1, cyclin D-binding Myb-like protein 1, cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1, DMP1FLJ76054, FLJ25188, FLJ41265, hDMP1DMTF, hDMTF1

Entrez Gene IDs

9988 (Human); 23857 (Mouse)

Gene Symbol

DMTF1

Additional DMTF1 Products

Product Documents for DMTF1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DMTF1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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