DOCK11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-32488

Novus Biologicals, part of Bio-Techne
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NBP2-32488
NBP2-32488-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (94%), Rat (94%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DOCK11 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: KDTVETAQDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DOCK11 Antibody

Immunocytochemistry/ Immunofluorescence: DOCK11 Antibody [NBP2-32488]

Immunocytochemistry/ Immunofluorescence: DOCK11 Antibody [NBP2-32488]

Immunocytochemistry/Immunofluorescence: DOCK11 Antibody [NBP2-32488] - Staining of human cell line RH-30 shows localization to nucleoli & nuclear membrane. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488]

Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488]

Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488] - Staining of human liver shows no positivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488]

Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488]

Immunohistochemistry-Paraffin: DOCK11 Antibody [NBP2-32488] - Staining of human testis shows moderate nuclear and cytoplasmic positivity in cells in seminiferus ducts.
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Applications for DOCK11 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DOCK11

DOCK11 (dedicator of cytokinesis 11) is also known as zizimin-2. It is a DOCK180-related guanine nucleotide exchange factor (GEF) for the small GTPase, Cdc42. As a GEF, DOCK11 functions to catalyze the dissociation of GDP from the GTPase. Dissociation of GDP allows an exchange for GTP and subsequent downstream signaling by the GTPase. Alternate names for DOCK11 include activated Cdc42-associated guanine nucleotide exchange factor, ACG, and ZIZ2.

Alternate Names

ACG, Activated Cdc42-associated guanine nucleotide exchange factor, Activated Cdc42-associated guanine nucleotide exchange factor, ACG, bB128O4.1, bB128O4.1.1 (novel protein), dedicator of cytokinesis 11, FLJ32122, FLJ43653, ZIZ2dedicator of cytokinesis protein 11, zizimin2, zizimin-2

Gene Symbol

DOCK11

Additional DOCK11 Products

Product Documents for DOCK11 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DOCK11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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