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Dopamine D3R/DRD3 Antibody (JE33-33)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32277

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32277

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JE33-33

Concentration

1 mg/ml

Product Summary for Dopamine D3R/DRD3 Antibody (JE33-33)

Immunogen

Synthetic peptide within Human Dopamine D3R/DRD3 aa 1-50 / 400. (Uniprot: P35462)

Localization

Cell membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

44 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Dopamine D3R/DRD3 Antibody (JE33-33)

Dopamine D3R/DRD3 Antibody (JE33-33)

Western Blot: Dopamine D3R/DRD3 Antibody (JE33-33) [NBP3-32277]

Western Blot: Dopamine D3R/DRD3 Antibody (JE33-33) [NBP3-32277] - Western blot analysis of Dopamine D3R/DRD3 on different lysates with Rabbit anti-Dopamine D3R/DRD3 antibody (NBP3-32277) at 1/1,000 dilution.

Lane 1: HeLa cell lysate (10 ug/Lane)
Lane 2: SH-SY5Y cell lysate (10 ug/Lane)
Lane 3: Mouse brain tissue lysate (20 ug/Lane)
Lane 4: Rat brain tissue lysate (20 ug/Lane)

Predicted band size: 44 kDa
Observed band size: 50 kDa

Exposure time: 2 minutes;

4-20% SDS-PAGE gel.

Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-32277) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:100,000 dilution was used for 1 hour at room temperature.

Applications for Dopamine D3R/DRD3 Antibody (JE33-33)

Application
Recommended Usage

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

1*TBS (pH7.4), 0.05% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dopamine D3 R/DRD3

The DRD3 Dopamine Receptor is expressed in brain regions associated with cognitive, emotional, and endocrine functions. DRD3 mediates the effects of drugs used in the treatment of schizophrenia and Parkinson's disease. DRD3 also binds BP897, a potent inhibitor of drug-craving and cocaine-seeking behaviors. Mutations in DRD3 lead to sodium retention in the kidney, resulting in hypertension and increased locomotor activity in mice. Multiple isoforms of DRD3 are produced by alternative splicing.

Long Name

Dopamine D3 Receptor

Alternate Names

D3DR, Dopamine D3R, DRD3, ETM1, FET1

Gene Symbol

DRD3

Additional Dopamine D3 R/DRD3 Products

Product Documents for Dopamine D3R/DRD3 Antibody (JE33-33)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Dopamine D3R/DRD3 Antibody (JE33-33)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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