Dopamine Receptor D4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24797

Novus Biologicals, part of Bio-Techne
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NBP3-24797
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (90%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Dopamine Receptor D4 Antibodies »

Product Specifications

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein Dopamine Receptor D4 using the following amino acid sequence: YSEVQGGAWLLSPRLCDALM

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Dopamine Receptor D4 Antibody

Dopamine Receptor D4 Antibody Immunocytochemistry/Immunofluorescence: Dopamine Receptor D4 Antibody [NBP3-24797]

Immunocytochemistry/Immunofluorescence: Dopamine Receptor D4 Antibody [NBP3-24797]

Staining of human cell line U2OS shows localization to plasma membrane.

Applications for Dopamine Receptor D4 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dopamine Receptor D4

DRD4, a Dopamine Receptor, has been suggested to affect personality, substance dependence, cognition, and emotion. DRD4 binds the antipsychotic medications clozapine and spiperone. DRD4 knock-out mice are anatomically normal but display altered locomotion and sensitivity to drugs such as clozapine, cocaine, and others. The DRD4 gene contains extensive polymorphisms consisting of variable numbers of tandem repeats (VNTR) in sequences corresponding to the third cytoplasmic loop of the receptor; at least 27 different haplotypes encoding 20 different protein variants have been documented. The frequency of the different variants varies among population groups. Studies have suggested a link between VNTR and human personality traits (such as novelty seeking) and diseases (such as schizophrenia, bipolar affective disorder, and Tourette syndrome); however, considerable debates exist regarding the validity and significance of such associations. DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens. ESTs have been isolated from a kidney library.

Long Name

D(4) dopamine receptor

Alternate Names

DRD4

Gene Symbol

DRD4

Additional Dopamine Receptor D4 Products

Product Documents for Dopamine Receptor D4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dopamine Receptor D4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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