DUSP10 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-82640

Novus Biologicals, part of Bio-Techne
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NBP1-82640
NBP1-82640-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DUSP10 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: FMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DUSP10 Antibody

Immunocytochemistry/ Immunofluorescence: DUSP10 Antibody [NBP1-82640]

Immunocytochemistry/ Immunofluorescence: DUSP10 Antibody [NBP1-82640]

Immunocytochemistry/Immunofluorescence: DUSP10 Antibody [NBP1-82640] - Staining of human cell line A-431 shows localization to nucleoplasm.
Immunohistochemistry-Paraffin: DUSP10 Antibody [NBP1-82640]

Immunohistochemistry-Paraffin: DUSP10 Antibody [NBP1-82640]

Immunohistochemistry-Paraffin: DUSP10 Antibody [NBP1-82640] - Staining of human kidney shows strong cytoplasmic positivity with granular pattern in renal tubules.

Applications for DUSP10 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DUSP10

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Alternate Names

dual specificity phosphatase 10, dual specificity phosphatase MKP-5, EC 3.1.3.16, EC 3.1.3.48, MAP kinase phosphatase 5, Mitogen-activated protein kinase phosphatase 5, MKP-5dual specificity protein phosphatase 10, MKP5serine/threonine specific protein phosphatase

Gene Symbol

DUSP10

Additional DUSP10 Products

Product Documents for DUSP10 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DUSP10 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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