DUSP14 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-16237

Novus Biologicals, part of Bio-Techne
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NBP2-16237
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DUSP14 Antibodies »

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human DUSP14. The exact sequence is proprietary.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for DUSP14 Antibody

Western Blot: DUSP14 Antibody [NBP2-16237]

Western Blot: DUSP14 Antibody [NBP2-16237]

Western Blot: DUSP14 Antibody [NBP2-16237] - Western Blot analysis of MKP-6 expression in transfected 293T cell line (20ug of whole cell ltsate) A: Non-transfected lysate. B: MKP-6 transfected lysate. 12% SDS PAGE gel, diluted at 1:1000.

Applications for DUSP14 Antibody

Application
Recommended Usage

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7), 40% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: DUSP14

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM]

Alternate Names

dual specificity phosphatase 14, EC 3.1.3.16, EC 3.1.3.48, MAP kinase phosphatase 6, Mitogen-activated protein kinase phosphatase 6, MKP-1 like protein tyrosine phosphatase, MKP-1-like protein tyrosine phosphatase, MKP-6, MKP6MKP-Ldual specificity protein phosphatase 14

Gene Symbol

DUSP14

UniProt

O95147 (Human)

Additional DUSP14 Products

Product Documents for DUSP14 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DUSP14 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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