Dynamin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-565

Novus Biologicals, part of Bio-Techne
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NB300-565
NB300-565-0.025ml
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

Immunocytochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Dynamin Antibodies »

Product Summary for Dynamin Antibody

Immunogen

Synthetic Peptide corresponding to resdiues C K(633) E K A S E T E E N G S D S F(647) of rat Dyn1.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Human

Localization

Microtubule associated.

Specificity

Dynamin 1 - Synapse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Dynamin Antibody

Western Blot: Dynamin Antibody [NB300-565]

Western Blot: Dynamin Antibody [NB300-565]

Western Blot: Dynamin Antibody [NB300-565] - Analysis of rat brain homogenate.

Applications for Dynamin Antibody

Application
Recommended Usage

Immunocytochemistry

1:10 - 1:500

Western Blot

1:1000
Application Notes
WB: Detects an approx. 100 kDa protein representing Dynamin 1 from rat whole brain extract.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Dynamin

The dynamins are a family of 100 kDa GTPases transcribed from at least three separate genes. At least four mRNA splice variants for each dynamin have been described. Dynamins contain several conserved regions including the conserved, amino-terminal GTPase domain, a centrally located membrane-binding plekstrin homology domain (PHD), and a coiled-coil region located in front of a proline-rich domain (PRD). The PRD is thought to mediate interactions between dynamin and numerous other cellular proteins. Dynamin I is expressed exclusively in neurons, dynamin II is ubiquitously expressed, and dynamin III is thought to be restricted to expression in the brain, testis, heart, and lung. The dynamins participate in the cellular process of clathrin-mediated and fluid-phase endocytosis.

Alternate Names

DNM1

Entrez Gene IDs

1759 (Human); 140694 (Rat)

Gene Symbol

DNM1

UniProt

P21575 (Rat)

Additional Dynamin Products

Product Documents for Dynamin Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dynamin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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