Dynamin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76558

Novus Biologicals, part of Bio-Techne
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NBP2-76558
NBP2-76558-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Dynamin Antibodies »

Product Summary for Dynamin Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PVDDSWLQVQSVPAGRRSPTSS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Dynamin Antibody

Immunocytochemistry/ Immunofluorescence: Dynamin Antibody [NBP2-76558]

Immunocytochemistry/ Immunofluorescence: Dynamin Antibody [NBP2-76558]

Immunocytochemistry/Immunofluorescence: Dynamin Antibody [NBP2-76558] - Staining of human cell line A549 shows localization to nucleoplasm. Antibody staining is shown in green.

Applications for Dynamin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dynamin

The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).

Alternate Names

DNM1

Gene Symbol

DNM1

Additional Dynamin Products

Product Documents for Dynamin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Dynamin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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