Dystonin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89946

Novus Biologicals, part of Bio-Techne
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NBP1-89946
NBP1-89946-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Dystonin Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KPRCQNVAEDMDIQLCASILNENSDENENINTMILLDKMHSCSSLEKQQRVNVVQLASPSENNLVTEKSNLPEYTTEIAGKSKENLLNHE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Dystonin Antibody

Immunocytochemistry/ Immunofluorescence: Dystonin Antibody [NBP1-89946]

Immunocytochemistry/ Immunofluorescence: Dystonin Antibody [NBP1-89946]

Immunocytochemistry/Immunofluorescence: Dystonin Antibody [NBP1-89946] - Staining of human cell line A-431 shows localization to nucleus & cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946]

Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946]

Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946] - Staining of human tonsil shows low positivity in non-germinal center cells as expected.
Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946]

Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946]

Immunohistochemistry-Paraffin: Dystonin Antibody [NBP1-89946] - Staining of human cerebellum shows weak to moderate cytoplasmic positivity in Purkinje cells.
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Applications for Dystonin Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50-1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dystonin

Dystonin encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been known that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.

Alternate Names

230 kDa bullous pemphigoid antigen, BP240, BPAFLJ30627, BPAG1FLJ32235, Bullous pemphigoid antigen, Bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, 230/240kDa, CATX-15, D6S1101, DKFZp564B2416, DMHCATX15, DT, Dystonia musculorum protein, dystonin, FLJ13425, FLJ21489, FLJ46791, Hemidesmosomal plaque protein, KIAA0465, KIAA0728, KIAA1470, MACF2, trabeculin-beta

Entrez Gene IDs

667 (Human)

Gene Symbol

DST

UniProt

Q03001 (Human)

Additional Dystonin Products

Product Documents for Dystonin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Dystonin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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