EDNRB/Endothelin R Type B Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS54

Novus Biologicals, part of Bio-Techne
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NLS54
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Canine

Cited:

Mouse

Predicted:

Primate (95%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all EDNRB/Endothelin R Type B Antibodies »

Product Specifications

Immunogen

Synthetic 19 amino acid peptide from N-terminal extracellular domain of human EDNRB/Endothelin R Type B.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 28459448). Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Monkey (89%), Marmoset (84%).

Localization

Multi-pass membrane protein

Specificity

Human EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for EDNRB/Endothelin R Type B Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunocytochemistry/ Immunofluorescence: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunocytochemistry/Immunofluorescence: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with transfected cells expressing Endothelin B Receptor at 4 ug/ ml.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NLS54] - Brain, Alzheimer's senile plaque
Immunocytochemistry/ Immunofluorescence: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunocytochemistry/ Immunofluorescence: EDNRB/Endothelin R Type B Antibody - BSA Free [NLS54]

Immunocytochemistry/Immunofluorescence: EDNRB/Endothelin R Type B Antibody [NLS54] - Analysis of anti-EDNRB / Endothelin B Receptor antibody with cells expressing vector only using this antibody at 4 ug/ ml.
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Applications for EDNRB/Endothelin R Type B Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

4-11 ug/ml

Western Blot

4-11 ug/ml
Application Notes
Use in ICC/IF reported in scientific literature (PMID : 28459448)..
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: EDNRB/Endothelin R Type B

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Long Name

Endothelin Receptor Type B

Alternate Names

EDNRB, ET-B, ETRB

Entrez Gene IDs

1910 (Human)

Gene Symbol

EDNRB

UniProt

P24530

Additional EDNRB/Endothelin R Type B Products

Product Documents for EDNRB/Endothelin R Type B Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for EDNRB/Endothelin R Type B Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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