Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 959507

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all EMAP-II Antibodies »

Product Specifications

Immunogen

E.coli-derived recombinant human EMAP-II
Ser147-Lys312
Accession # Q12904

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for EMAP-II/AIMP1 Antibody (959507)

Western Blot: EMAP-II/AIMP1 Antibody (959507) [MAB19101]

Western Blot: EMAP-II/AIMP1 Antibody (959507) [MAB19101]

Western Blot: EMAP-II/AIMP1 Antibody (959507) [MAB19101] - Detection of Human, Mouse, and Rat EMAP-II by Western Blot. Western blot shows lysates of Daudi, SK-OV-3, M1, Neuro2A and Rat-2 cell lysates. PVDF membrane was probed with Mouse Anti-Human EMAP-II Monoclonal Antibody (Catalog # MAB19101) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for EMAP-II at approximately 38 kDa (as indicated). This experiment was conducted under reducing conditions

Applications for EMAP-II/AIMP1 Antibody (959507)

Application
Recommended Usage

Immunocytochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: EMAP-II

EMAP II (Endothelial-Monocyte-Activating Polypeptide II) is a proinflammatory cytokine and chemoattractant of macrophages and polymorphonuclear lymphocytes. EMAP II is synthesized as a 34 kDa precursor molecule which is cleaved to a biologically active 22 kDa mature polypeptide. This active protein is known to induce the procoagulant protein tissue factor on the surface of endothelial cells and modulate other properties of endothelial cells and monocytes in vitro, including the stimulation of TNF-alpha and myeloperoxidase. EMAP II activates neutrophils in vivo and induces an inflammatory reaction and tumor regression. EMAP II induces apoptosis in proliferating endothelial cells and inhibits neovascularization. This anti-angiogenic property is of interest to tumor biology. EMAP II is also a negative modulator of lung vascular growth.

Long Name

Endothelial-Monocyte Activating Polypeptide II

Alternate Names

AIMP1, EMAPII, SCYE1

Gene Symbol

AIMP1

Additional EMAP-II Products

Product Documents for EMAP-II/AIMP1 Antibody (959507)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for EMAP-II/AIMP1 Antibody (959507)

0

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.