Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all EPC1 Antibodies »

Product Specifications

Immunogen

The immunogen for this product maps to a region between residue 325 and 375 of human Enhancer of Polycomb 1 using the numbering given in entry NP_079485.1 (GeneID 80314).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for EPC1 Antibody

Western Blot: EPC1 Antibody [NBP1-71865]

Western Blot: EPC1 Antibody [NBP1-71865]

Western Blot: EPC1 Antibody [NBP1-71865] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-EPC1 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. EPC1 was also immunoprecipitated by another rabbit anti-EPC1 antibody.,

Applications for EPC1 Antibody

Application
Recommended Usage

Immunoprecipitation

2-10 mcg/mg

Western Blot

1:2000-1:10000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: EPC1

EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Alternate Names

DKFZp781P2312, enhancer of polycomb 1, enhancer of polycomb homolog 1, enhancer of polycomb homolog 1 (Drosophila), Epl1

Gene Symbol

EPC1

UniProt

NP_079485.1 (Human)

Additional EPC1 Products

Product Documents for EPC1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for EPC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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