ErbB3/Her3 Antibody (patritumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28184

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-28184-100ug
NBP3-28184-50ug
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # patritumab

Concentration

LYOPH mg/ml

View all ErbB3/Her3 Antibodies »

Product Specifications

Immunogen

ERBB3 / HER3

Reactivity Notes

Predicted species reactivity: Rat

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'patritumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for ErbB3/Her3 Antibody (patritumab)

ErbB3/Her3 Antibody (patritumab)

ELISA: ErbB3/Her3 Antibody (patritumab)[NBP3-28184] -

Immobilized human HER3 His at 2 ug/mL can bind ErbB3/Her3 Antibody (patritumab), EC50=0.04264 ug/mL.
ErbB3/Her3 Antibody (patritumab)

Flow Cytometry: ErbB3/Her3 Antibody (patritumab)[NBP3-28184] -

Human HER3 HEK293 cells were stained with ErbB3/Her3 Antibody (patritumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.2297 ug/mL.

Applications for ErbB3/Her3 Antibody (patritumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: ErbB3/Her3

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Long Name

Receptor Tyrosine Protein Kinase ErbB3

Alternate Names

HER3

Gene Symbol

ERBB3

UniProt

P21860

Additional ErbB3/Her3 Products

Product Documents for ErbB3/Her3 Antibody (patritumab)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ErbB3/Her3 Antibody (patritumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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