ErbB3/Her3 Antibody (S05-3F7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19862

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19862-100ul
NBP3-19862-50ul
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-3F7

Concentration

0.3 mg/ml

View all ErbB3/Her3 Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human ErbB3/Her3 (Uniprot # P21860)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

185 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ErbB3/Her3 Antibody (S05-3F7)

Western Blot: ErbB3/Her3 Antibody (S05-3F7) [NBP3-19862]

Western Blot: ErbB3/Her3 Antibody (S05-3F7) [NBP3-19862]

Western Blot: ErbB3/Her3 Antibody (S05-3F7) [NBP3-19862] - Western blot detection of ErbB3/Her3 in A549 (Lane 1), MCF-7 (Lane 2) cell lysates using NBP3-19862 (1:1000 diluted). Predicted band size: 148kDa. Observed band size: 185kDa.

Applications for ErbB3/Her3 Antibody (S05-3F7)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ErbB3/Her3

The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.

Long Name

Receptor Tyrosine Protein Kinase ErbB3

Alternate Names

HER3

Gene Symbol

ERBB3

Additional ErbB3/Her3 Products

Product Documents for ErbB3/Her3 Antibody (S05-3F7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ErbB3/Her3 Antibody (S05-3F7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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