ERR gamma/NR3B3 Antibody (SR1899)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22303

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22303-100ul
NBP3-22303-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1899

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ERR gamma/NR3B3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human ERR gamma/NR3B3 (Uniprot #: P62508)

Specificity

Detects endogenous levels of total ERR gamma/NR3B3

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for ERR gamma/NR3B3 Antibody (SR1899)

Western Blot: ERR gamma/NR3B3 Antibody (SR1899) [NBP3-22303] -

Western Blot: ERR gamma/NR3B3 Antibody (SR1899) [NBP3-22303] - Western blot analysis using NBP3-22303 in Human fetal heart lysate.

Applications for ERR gamma/NR3B3 Antibody (SR1899)

Application
Recommended Usage

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ERR gamma/NR3B3

Estrogen related receptor (ERR gamma), a NR3 Steroid Receptor is an orphan member of the nuclear hormone receptor superfamily. All the ERR family members (1,2, and 3) share an almost identical DNA binding domain, which has 68% amino acid identity with that of estrogen receptor. Studies involving the crystal structure of the LBD have shown a complex between ERR3 and SRC1. ERR gamma has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In humans, ERR gamma pre mRNA undergoes extensive alternative splicing at the 5 prime end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development.

Long Name

Estrogen-related Receptor gamma

Alternate Names

ERR3, ESRRG, NR3B3

Gene Symbol

ESRRG

Additional ERR gamma/NR3B3 Products

Product Documents for ERR gamma/NR3B3 Antibody (SR1899)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ERR gamma/NR3B3 Antibody (SR1899)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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