FAIM3 Antibody (1E4)

Novus Biologicals, part of Bio-Techne | Catalog # H00009214-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

ELISA, Flow Cytometry, Immunohistochemistry, Western Blot

Cited:

Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 1E4

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Fc mu R/FAIM3 Antibodies »

Product Specifications

Immunogen

FAIM3 (AAH06401, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQ

Reactivity Notes

Other species not tested.

Specificity

FAIM3 - Fas apoptotic inhibitory molecule 3

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for FAIM3 Antibody (1E4)

Western Blot: FAIM3 Antibody (1E4) [H00009214-M01]

Western Blot: FAIM3 Antibody (1E4) [H00009214-M01]

Western Blot: FAIM3 Antibody (1E4) [H00009214-M01] - FAIM3 monoclonal antibody (M01), clone 1E4 Analysis of FAIM3 expression in K-562.
Western Blot: FAIM3 Antibody (1E4) [H00009214-M01]

Western Blot: FAIM3 Antibody (1E4) [H00009214-M01]

Western Blot: FAIM3 Antibody (1E4) [H00009214-M01] - Analysis of FAIM3 expression in transfected 293T cell line by FAIM3 monoclonal antibody (M01), clone 1E4.Lane 1: FAIM3 transfected lysate(43.1 KDa).Lane 2: Non-transfected lysate.
ELISA: FAIM3 Antibody (1E4) [H00009214-M01]

ELISA: FAIM3 Antibody (1E4) [H00009214-M01]

ELISA: FAIM3 Antibody (1E4) [H00009214-M01] - ELISA analysis of FAIM3 in PBMC CD14 negative fraction. Image courtesy of anonymous customer product review.
View 1 more images

Applications for FAIM3 Antibody (1E4)

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1:500
Application Notes
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. Use in FLOW cytometry reported in scientific literature ( PMID 25769920)

Reviewed Applications

Read 1 review rated 3 using H00009214-M01 in the following applications:

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Fc mu R/FAIM3

Apoptosis is an important process in maintaining normal tissue homeostasis and function. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas associated death domain (FADD), containing death inducing signalling complex, and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7 (Curting and Cotter, 2003). Recent experiments have shown that overexpression of FAIM3, a novel regulator of Fas induced apoptosis in lymphoid cells, Jurkat cells and in transgenic mice renders these cells resistant to Fas induced apoptosis but not to TRAIL induced apoptosis (Hitoshi et al, 1998; Song and Jacob, 2005). Furthermore, FAIM3 was found to associate with FADD, suggesting that it functions by disrupting the formation of the death inducing signalling complex. Despite its predicted molecular weight, FAIM3 often migrates at 60 kDa in SDS PAGE.

Long Name

Fc mu Receptor

Alternate Names

FAIM3, FCMR, Toso

Entrez Gene IDs

9214 (Human)

Gene Symbol

FCMR

OMIM

606015 (Human)

UniProt

AAH06401 (Human)

Additional Fc mu R/FAIM3 Products

Product Documents for FAIM3 Antibody (1E4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FAIM3 Antibody (1E4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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