FAIM3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76458

Novus Biologicals, part of Bio-Techne
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NBP1-76458
NBP1-76458-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Fc mu R/FAIM3 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Toso. The immunogen is located within the first 50 amino acids of Toso. Amino Acid Squence: KVEGELGGSVTIK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FAIM3 Antibody - BSA Free

Western Blot: FAIM3 AntibodyBSA Free [NBP1-76458]

Western Blot: FAIM3 AntibodyBSA Free [NBP1-76458]

Western Blot: FAIM3 Antibody [NBP1-76458] - Analysis of TOSO in K562 cell lysate with TOSO antibody at (A) 1 and (B) 2 ug/mL.

Applications for FAIM3 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Fc mu R/FAIM3

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.

Long Name

Fc mu Receptor

Alternate Names

FAIM3, FCMR, Toso

Gene Symbol

FCMR

UniProt

NP_005440

Additional Fc mu R/FAIM3 Products

Product Documents for FAIM3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FAIM3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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