FANCE Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49878

Novus Biologicals, part of Bio-Techne
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NBP1-49878
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all FANCE Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-EHKSLESLADGGS corresponding to internal region according to NP_068741.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for FANCE Antibody

Immunohistochemistry-Paraffin: FANCE Antibody [NBP1-49878]

Immunohistochemistry-Paraffin: FANCE Antibody [NBP1-49878]

Immunohistochemistry-Paraffin: FANCE Antibody [NBP1-49878] - Staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for FANCE Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 6 ug/ml

Immunohistochemistry-Paraffin

3 - 6 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

1:100 - 1:2000
Application Notes
WB: Preliminary experiments gave an approx. 70 kDa band in human adipose and uterus lysates after 0.1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 58.7 kDa band according to NP_068741.1. The 70 kDa band was successfully blocked by incubation with the immunizing peptide. IHC-P: Human placenta shows nuclear staining in some trophoblasts.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FANCE

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group E. [provided by RefSeq]

Alternate Names

FACEFAE, Fanconi anemia group E protein, Fanconi anemia, complementation group E, Protein FACE

Entrez Gene IDs

2178 (Human)

Gene Symbol

FANCE

UniProt

NP_068741.1 (Human)

Additional FANCE Products

Product Documents for FANCE Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FANCE Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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