FANCI [p Ser559] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-60781

Novus Biologicals, part of Bio-Techne
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NBP2-60781
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all FANCI Antibodies »

Product Summary for FANCI [p Ser559] Antibody

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser556 conjugated to KLH. Accession # Q9NVI1

Modification

p Ser559

Specificity

Specific for endogenous levels of the ~150 kDa FANCI protein phosphorylated at Ser559. Immunolabeling is increased when HeLa cells are treated with 256nm UV light for 20 minutes and completely eliminated by treatment with lambda-phosphatase.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

150 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FANCI [p Ser559] Antibody

Western Blot: FANCI [p Ser559] Antibody [NBP2-60781]

Western Blot: FANCI [p Ser559] Antibody [NBP2-60781]

Western Blot: FANCI [p Ser559] Antibody [NBP2-60781] - Western blot of Hela cell lysate treated with UV (~254nm) for20' showing specific immunolabeling of the ~150 kDa FANCIprotein phosphorylated at Ser559 in the first lane (-).Phosphospecificity is shown in the second lane (+) whereimmunolabeling is completely eliminated by blot treatment withlambda phosphatase (Lambda-Ptase, 1200 units for 30 min).
Western Blot: FANCI [p Ser559] Antibody [NBP2-60781]

Western Blot: FANCI [p Ser559] Antibody [NBP2-60781]

Western Blot: FANCI [p Ser559] Antibody [NBP2-60781] - Western blot of HeLa cell lysates that had been treated withUV (~254 nm) for 0' or 20' showing specific immunolabeling of the~150 kDa FANCI protein phosphorylated at Ser559.

Applications for FANCI [p Ser559] Antibody

Application
Recommended Usage

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10 mM HEPES (pH 7.5), 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: FANCI

FANCI is the gene underlying Fanconi anemia complementation group I, a syndrome characterized by a predisposition to cancer, congenital malformations, and pancytopenia. At the cellular level, FANCI is involved in the S and G2 phase DNA damage checkpoint and in the repair of DNA double-strand breaks and cross-links.

Alternate Names

Fanconi anemia group I protein, Fanconi anemia, complementation group I, KIAA1794FLJ10719, Protein FACI

Gene Symbol

FANCI

Additional FANCI Products

Product Documents for FANCI [p Ser559] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FANCI [p Ser559] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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