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FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28355

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # rozanolixizumab

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

FcRn (FCGRT & B2M)

Reactivity Notes

Predicted species reactivity: Cynomolgus

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'rozanolixizumab'.

IgG4SP is human IgG4 with S228P mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

ELISA: FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP[NBP3-28355] -

Immobilized FcRn (FCGRT) His+FcRn (B2M) at 2 ug/mL can bind FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP, EC50=0.0103 ug/mL.

Applications for FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: FCRN

The FCGRT gene encodes a 365 amino acid long, 39 kDA IgG receptor FcRn large subunit p51 protein that transfers immunoglobulin G antibodies across the placenta from mother to fetus, as well as functions to protect the antibody from degradation. FCGRT interacts with genes CA6, ELANE, AZGP1, B2M, and ALB. It has been linked to diseases such as: lupus, nephritis, leukemia, arthritis, immunodeficiency, epidermolysis bullosa acquisita, persistent fetal circulation syndrome, and pemphigus.

Long Name

Neonatal Fc Receptor

Alternate Names

FCGRT

Gene Symbol

FCGRT

UniProt

Additional FCRN Products

Product Documents for FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for FCRN/FCGRT Antibody (rozanolixizumab) - Humanized, IgG4SP

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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