FCRN/FCGRT Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89127

Novus Biologicals, part of Bio-Techne
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NBP1-89127
NBP1-89127-25ul
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Key Product Details

Species Reactivity

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western

Cited:

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FCRN Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FCRN/FCGRT Antibody

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127] - Staining of human skin shows weak membranous positivity in fibroblasts.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127] - Staining of human liver shows weak membranous positivity in Kupffer cells.
Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127]

Immunohistochemistry-Paraffin: FCRN/FCGRT Antibody [NBP1-89127] - Staining of human placenta shows weak membranous positivity in Hofbauer cells.
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Applications for FCRN/FCGRT Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Simple Western

Reported by internal validation
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. In Simple Western internal validation: Hepatocyte as sample; separated by size; antibody dilution of 1:50; observed molecular weight was 64 kDa; matrix was 12-230 kDa; detected by Chemiluminescence.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FCRN

The FCGRT gene encodes a 365 amino acid long, 39 kDA IgG receptor FcRn large subunit p51 protein that transfers immunoglobulin G antibodies across the placenta from mother to fetus, as well as functions to protect the antibody from degradation. FCGRT interacts with genes CA6, ELANE, AZGP1, B2M, and ALB. It has been linked to diseases such as: lupus, nephritis, leukemia, arthritis, immunodeficiency, epidermolysis bullosa acquisita, persistent fetal circulation syndrome, and pemphigus.

Long Name

Neonatal Fc Receptor

Alternate Names

FCGRT

Entrez Gene IDs

2217 (Human)

Gene Symbol

FCGRT

UniProt

P55899

Additional FCRN Products

Product Documents for FCRN/FCGRT Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FCRN/FCGRT Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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