FE65 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48682

Novus Biologicals, part of Bio-Techne
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NBP2-48682
NBP2-48682-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FE65 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: QEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGI

Reactivity Notes

Mouse (86%), Rat (86%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FE65 Antibody

Immunocytochemistry/ Immunofluorescence: FE65 Antibody [NBP2-48682]

Immunocytochemistry/ Immunofluorescence: FE65 Antibody [NBP2-48682]

Immunocytochemistry/Immunofluorescence: FE65 Antibody [NBP2-48682] - Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane.
Immunohistochemistry-Paraffin: FE65 Antibody [NBP2-48682]

Immunohistochemistry-Paraffin: FE65 Antibody [NBP2-48682]

Immunohistochemistry-Paraffin: FE65 Antibody [NBP2-48682] - Staining of human cerebral cortex shows neuropil and cytoplasmic positivity in neurons.

Applications for FE65 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FE65

Amyloid beta A4 precursor protein-binding family B member 1, also known as FE65, is a signaling adaptor of APP protein. The FE65/APP complex has been shown to translocate into the cell nucleus and regulate gene expression, indicating that FE65 may be critical in the pathogenesis of Alzheimer's disease. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer's Disease patients.

FE65 antibodies are useful tools for research on Alzheimer's disease progression.

Alternate Names

adaptor protein FE65a2, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65), amyloid beta A4 precursor protein-binding, family B, member 1, Fe65, FE65amyloid beta A4 precursor protein-binding family B member 1, MGC:9072, Protein Fe65, RIR, stat-like protein

Gene Symbol

APBB1

Additional FE65 Products

Product Documents for FE65 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FE65 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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