Fetal Hemoglobin Antibody (SR1113)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22184

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22184-100ul
NBP3-22184-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1113

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Fetal Hemoglobin Antibodies »

Product Summary for Fetal Hemoglobin Antibody (SR1113)

Immunogen

A synthesized peptide derived from human Fetal Hemoglobin (Uniprot #: P69891, P69892)

Specificity

Detects endogenous levels of total Fetal Hemoglobin

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

12 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Fetal Hemoglobin Antibody (SR1113)

Western Blot: Fetal Hemoglobin Antibody (SR1113) [NBP3-22184] -

Western Blot: Fetal Hemoglobin Antibody (SR1113) [NBP3-22184] - Western blot analysis using NBP3-22184 in K562 cell lysate.

Applications for Fetal Hemoglobin Antibody (SR1113)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Fetal Hemoglobin

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Alternate Names

abnormal hemoglobin, A-gamma globin, gamma A hemoglobin, gamma globin, gamma-1-globin, gamma-2-globin, gamma-globin chain, G-gamma globin Paulinia, Hb F Agamma, hb F Ggamma, HBGA, HBGR, HBG-T1, HBG-T2, Hemoglobin gamma-1 chain, hemoglobin gamma-2 chain, Hemoglobin gamma-A chain, hemoglobin gamma-G chain, hemoglobin subunit gamma-1, hemoglobin subunit gamma-2, hemoglobin, gamma A, hemoglobin, gamma, regulator of, HSGGL1, methemoglobin, PRO2979

Gene Symbol

HBG1

Additional Fetal Hemoglobin Products

Product Documents for Fetal Hemoglobin Antibody (SR1113)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Fetal Hemoglobin Antibody (SR1113)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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