FGL2/Fibroleukin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87199

Novus Biologicals, part of Bio-Techne
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NBP1-87199
NBP1-87199-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FGL2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SQEQIQSRPVQHLIYKDCSDYYAIGKRSSETYRVTPDPKNSSFEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (85%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FGL2/Fibroleukin Antibody

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199] - Staining of human spleen shows strong cytoplasmic positivity in cells in red pulp.
Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199] - Analysis in human spleen and pancreas tissues. Corresponding FGL2/Fibroleukin RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199]

Immunohistochemistry-Paraffin: FGL2/Fibroleukin Antibody [NBP1-87199] - Staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.
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Applications for FGL2/Fibroleukin Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FGL2

FGL2 (fibrinogen-like protein 2), also called fibroleukin, is a 64-70 kDa secreted glycoprotein of the Fibrinogen-like superfamily. In the presence of acidic phospholipids and calcium, FGL2 has prothrombinase activity and acts as a procoagulant. In soluble form, FGL2 promotes T regulatory (Treg) activity and suppresses DC, T, and B cell immune reactivity, acting as an immune suppressor. A 260-280 aa FGL2 complex is thought to be a homotetramer.

Long Name

Fibrinogen-like 2

Alternate Names

Fibroleukin, T49

Gene Symbol

FGL2

Additional FGL2 Products

Product Documents for FGL2/Fibroleukin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FGL2/Fibroleukin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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