FIV gp95 Antibody (SU1-30)

Unconjugated

Monoclonal Mouse IgG₁ Clone # SU1-30

1.0 mg/ml

Made to FIV gp95

NB100-64378 specifically recognizes the relatively conserved E60 peptide (amino acid sequence SSWKQRNRWEWRPDF) located within the V3 region of FIV (Feline Immunodeficiency Virus) envelope glycoprotein SU,gp95. The primary receptor for FIV infection of cats has been identified as the T-cell activation antigen CD134 which, along with CXC chemokine receptor 4 (CXCR4), facilitates the infection of CD4+ primary target cells, resulting in a depletion in the CD4+ population. Studies have shown that the V3 loop of SU,gp95 is a major immunogenic domain, suggested to contain the main determinants for the binding of FIV SU,gp95 to CXCR4.(3) Clone SU1-30 has been shown to inhibit the sCD134-activated entry of both clade B and clade C FIV strains.(1) NB100-64378 does not recognize Feline Leukaemia Virus, Feline Herpes Virus type 1, Feline Coronavirus or Feline Calicivirus. Removal of Sodium Azide is recommended prior to use in functional studies.

Monoclonal

Mouse

IgG₁

Protein A purified

PBS

<0.1% Sodium Azide

1.0 mg/ml

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.