FOXO1A/3/4 Antibody (4E7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-41196

Novus Biologicals, part of Bio-Techne
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NBP1-41196
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 4E7

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FOXO1A/3/4 Antibodies »

Product Specifications

Immunogen

Amino acids 242-655 of FKHR expressed in E. coli.

Specificity

This antibody will recognize human FKHR.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FOXO1A/3/4 Antibody (4E7)

Immunohistochemistry: FOXO1A/3/4 Antibody (4E7) [NBP1-41196]

Applications for FOXO1A/3/4 Antibody (4E7)

Application
Recommended Usage

Immunohistochemistry

1:10 - 1:500

Western Blot

0.1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FOXO1A/3/4

FKHR-7H3 recognizes FKHR (ForKHead in Rhabdomyosarcoma), a 70a protein, which is a member of the forkhead homeotic gene family of transcription factors (FKH/HNF-3). Members of the forkhead family can be classified and grouped by their degree of homology within the 100-120aa region that is necessary and sufficient for DNA binding and binding-site specificity. The FKHR subfamily of forkhead proteins is relatively divergent from the other members of the forkhead transcription factor family. With all members in this subfamily containing a signature insertion of 5 amino acids next to the helix 3 in the middle of the forkhead domain, and lack the well conserved amino terminal KPPY sequence found in most forkhead genes. Recently, it has been shown that members of the FKHR gene family are phosphorylated by Akt and this phosphorylation regulates its cellular localization promoting cell survival.

Alternate Names

FKH1, FKHRforkhead box protein O1, forkhead box O1, Forkhead box protein O1A, forkhead homolog in rhabdomyosarcoma, Forkhead in rhabdomyosarcoma, FOXO1Aforkhead, Drosophila, homolog of, in rhabdomyosarcoma

Entrez Gene IDs

2308 (Human)

Gene Symbol

FOXO1

Additional FOXO1A/3/4 Products

Product Documents for FOXO1A/3/4 Antibody (4E7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FOXO1A/3/4 Antibody (4E7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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