Frizzled-2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS3488

Novus Biologicals, part of Bio-Techne
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NLS3488
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Hamster

Predicted:

Sheep (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all Frizzled-2 Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide from 3rd extracellular domain of human Frizzled-2.

Epitope

3rd extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Opossum (89%), Turkey (83%), Chicken (83%), Xenopus (83%).

Localization

Integral membrane protein

Specificity

Human Frizzled-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD7 (67%), OR1A2 (56%), NFATC2 (50%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for Frizzled-2 Antibody - BSA Free

Immunohistochemistry-Paraffin: Frizzled-2 Antibody - BSA Free [NLS3488]

Immunohistochemistry-Paraffin: Frizzled-2 Antibody - BSA Free [NLS3488]

Immunohistochemistry-Paraffin: Frizzled-2 Antibody [NLS3488] - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry-Paraffin: Frizzled-2 Antibody - BSA Free [NLS3488]

Immunohistochemistry-Paraffin: Frizzled-2 Antibody - BSA Free [NLS3488]

Immunohistochemistry-Paraffin: Frizzled-2 Antibody [NLS3488] - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Frizzled-2 Antibody - BSA Free

Immunohistochemistry: Frizzled-2 Antibody - BSA Free [NLS3488] -

Immunohistochemistry: Frizzled-2 Antibody - BSA Free [NLS3488] - Immunohistochemistry of Lung, Non Small-Cell Carcinoma

Applications for Frizzled-2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

5-10 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: Frizzled-2

FZD2 is a Frizzled Receptor that mediates Wnt signaling, which is required for proper axis development in the embryo. FZD2 is developmentally regulated. Studies of rat FZD2 indicate that the protein signals through a calcium-releasing pathway and that FDZ2 expression modulates protein kinase C (PKC) localization and stimulates PKC activity in vitro. Increased levels of FZD2 mRNA have been observed in primary gastric cancer and in head and neck squamous carcinoma and gastric cancer cell lines. FZD2 expression has been documented in human brain, heart, kidney, lung, colon, ovary and stomach. High levels of expression have been observed in fetal kidney and lung and adult colon and ovary. ESTs have been isolated from human tissue libraries, including cancerous kidney, lung, lymph and testis, and normal blood, cervix, embryo and kidney.

Alternate Names

Frizzled2, FZD2

Entrez Gene IDs

2535 (Human); 57265 (Mouse)

Gene Symbol

FZD2

Additional Frizzled-2 Products

Product Documents for Frizzled-2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Frizzled-2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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