Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all FRMPD1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human FRMPD1. The immunogen is located within amino acids 1330 - 1380 of FRMPD1. Amino Acid Squence: CFRGLQPETEEEDED

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FRMPD1 Antibody - BSA Free

Western Blot: FRMPD1 AntibodyBSA Free [NBP1-77082]

Western Blot: FRMPD1 AntibodyBSA Free [NBP1-77082]

Western Blot: FRMPD1 Antibody [NBP1-77082] - K562 cell lysate with FRMPD1 antibody at (A) 1 and (B) 2 ug/mL.
FRMPD1 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: FRMPD1 Antibody - BSA Free [NBP1-77082] -

Immunocytochemistry/ Immunofluorescence: FRMPD1 Antibody - BSA Free [NBP1-77082] - Immunofluorescence of FRMPD1 in K562 cells with FRMPD1 antibody at 20 u/mL.

Applications for FRMPD1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5 ug/mL

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FRMPD1

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD1 was initially identified through a yeast two-hybrid screening with Activator of G-protein signaling 3 (AGS3), a protein that acts to stabilize the GDP-bound conformation of Gai, as the bait. FRMPD1 binds to the tetratricopeptide repeat of AGS3 and stabilizes AGS3 in a membrane environment. Suppression of FRMPD1 in Cath.a-differentiated neuronal cells decreased the level of endogenous AGS3 in membrane fractions by ~50% and enhanced the inhibition of forskolin-induced increases in cAMP. Co-immunoprecipitation studies indicate that the interaction of AGS3 with FRMPD1 is mutually exclusive with the interaction of AGS3 with Gai3, suggesting that FRMPD1 may position AGS3 in the membrane where it can then interact with Galphai.

Alternate Names

FERM and PDZ domain containing 1, FERM and PDZ domain-containing protein 1, FRMD2KIAA0967FERM domain-containing protein 2, MGC138833

Gene Symbol

FRMPD1

UniProt

NP_055722 (Human)

Additional FRMPD1 Products

Product Documents for FRMPD1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FRMPD1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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