Fumarase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-61663

Novus Biologicals, part of Bio-Techne
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NB100-61663
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Fumarase Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-HPNDHVNKSQSSND corresponding to internal region according to NP_000134.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Fumarase Antibody

Western Blot: Fumarase Antibody [NB100-61663]

Western Blot: Fumarase Antibody [NB100-61663]

Western Blot: Fumarase Antibody [NB100-61663] - Staining of Human Kidney lysate (35 ug protein in RIPA buffer). Antibody at 0.01 ug/mL. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663]

Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663]

Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663] - Staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Antibody at 3.75 ug/mL.
Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663]

Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663]

Immunohistochemistry-Paraffin: Fumarase Antibody [NB100-61663] - Staining of paraffin embedded Human Skeletal Muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Antibody at 3.75 ug/mL.

Applications for Fumarase Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

3.75 ug/mL

Peptide ELISA

Detection limit 1:64000

Western Blot

0.01 - 0.03 ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Fumarase

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.

Alternate Names

EC 4.2.1.2, Fumarase, fumarate hydratase, fumarate hydratase, mitochondrial, HLRCC, LRCC, MCL, MCUL1

Entrez Gene IDs

2271 (Human); 14194 (Mouse); 24368 (Rat)

Gene Symbol

FH

UniProt

P07954 (Human)

Additional Fumarase Products

Product Documents for Fumarase Antibody

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Certificate of Analysis

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Product Specific Notices for Fumarase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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