FXR2 Antibody (1G2) [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NB300-259V

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 1G2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all FXR2 Antibodies »

Product Specifications

Immunogen

Recombinant C-terminal fragment of human FXR2 (residues 414-658). [UniProt# P51116]

Localization

Cytoplasmic

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for FXR2 Antibody (1G2) [DyLight 405]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FXR2

FXR2 (Fragile X relative protein 2) belongs to FMR1 family/fragile X mental retardation proteins which can bind to RNA and associate with polyribosomes. All three members of FMR1 proteins i.e. FMRP, FXR1, and FXR2 contains RNA-binding domains and RGG boxes, and are found predominantly in cytoplasm where they can associate with ribosomes for implicating translation or mRNA stability. FXR2 has been shown to interact with FMR1, FXR1, CYFIP2 and TDRD3. It is ubiquitously expressed during embryonic development and its tissue distribution overlaps with FMRP in adult stages. However, interestingly, FXR2 knockout mice display learning impairments and changes in synaptic plasticity that are somewhat distinct from those of FMRP-deficient mice, indicating that FXR2 may also regulate adult hippocampal neurogenesis via mechanisms distinct from FMRP. FXR2 deficiency leads to altered stem cell proliferation and differentiation specifically in dentate gyrus and not in subventricular zone which has been suggested as a key component of mechanism regulating differential neurogenic processes in these two adult germinal zones.

Alternate Names

FMR1L2, fragile X mental retardation syndrome-related protein 2, fragile X mental retardation, autosomal homolog 2, fragile X-mental retardation 1-like 2, FXR2P

Gene Symbol

FXR2

Additional FXR2 Products

Product Documents for FXR2 Antibody (1G2) [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FXR2 Antibody (1G2) [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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